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Rom J Morphol Embryol. 2009;50:719
The importance of histopathologic aspects in of dissecting cellulitis of the scalp.
hair loss blog edited
Dissecting cellulitis of the scalp or dissecting folliculitis also known as "perifoliculitis capitis abscedens et suffodiens" (PCAS), is a rare, severe and distinct dermatological disease and cause of hair loss. It most probably occurs because of follicular occlusion via hyperkeratosis, having the same mechanism of acnea conglobata and hidradenitis suppurativa. These dermatoses may be associated or may have an isolated evolution. PCAS is one of the primitive cicatricial air loss of neutrophilic type. What is characteristic for the histopathologic picture of the disease is the deep inflammatory infiltrate, placed at the reticular derm or hypoderm level. snip.. Here is the case of a 24-year-old male with records of acne conglobata and cicatricial hair loss of the scalp, with relapsed inflammatory nodular lesions on the surface of the alopecic plaques and follicular pustules on their margin. The patient had followed before hospitalizing a systemic treatment with antibiotics (azithromycin, tetracycline, ciprofloxacin, in therapeutic schemes that the patient cannot mention, but anyway of short time) and after that a treatment with retinoids (isotretinoin, 20-30 mg/day, in two successive therapies of one month each). The evolution of the disease under these treatments was with outbreaks and short times of remission of the acne lesions and nodular lesions of the scalp. The clinical diagnosis of PCAS is difficult, especially in the initial stage of the disease, as it was the case of the patient presented here. snip....
edited for hair loss blog use
Doru T et al
Dermatology Online Journal 15: 1
....better understanding of the EGF family ligands and receptors, as well as their interplay and physiological phases, has the potential to produce a revolution in the treatment of hair loss. Availability of topical EGFR blockers and the development of more specific molecules that will stimulate the hair regrowth pathways will build on the fact that EGFR blockade can produce long-term hair growth. An apparent lack of tolerance to the hair regrowth effect after long term treatment, as recently seen, contrasts with other systemic and cutaneous toxicities of medications from the EGFR blocking class, thus creating the possibility of clinically relevant long-lasting effects.
Edited for hair loss blog use
Can Vet J. 2009 May; 50(5): 511–514. PMCID: PMC2671874
Copyright and/or publishing rights held by the Canadian Veterinary Medical Association
Color dilution alopecia in a blue Doberman pinscher crossbreed
Roberta Perego, et al
A 6-year-old male, blue Doberman pinscher crossbreed was presented with coat abnormalities; in particular, flank hair loss and pruritus. Based on medical the history, clinical evidence, and histopathological examination, color dilution alopecia was diagnosed. The dog was with oral melatonin treated for 3 months without success.
Alopécie à dilution de couleur chez une race croisée de Doberman Pinscher bleu. Un Doberman Pinscher âgé de 6 ans est présenté avec des anomalies du pelage; en particulier, une alopécie du flanc et du prurit. En fonction de l’anamnèse, des signes cliniques et de l’examen histopathologique, l’alopécie à dilution de couleur a été diagnostiquée. Le chien a été traité sans succès à la mélatonine pendant 3 mois.(Traduit par Isabelle Vallières)
Psoriatic alopecia: acute and chronic hair loss in 47 patients with scalp psoriasis.
Runne U, Kroneisen-Wiersma P.
Symptomatic hair loss and alopecia were seen in psoriatic lesions of the scalp in 47 patients. snip... Hair loss varied in intensity from protracted to moderate and massive (36% in tufts). It presented as acute (51%), chronic (36%) or chronic recurrent (13%). Thirteen patients (28%) became aware of the hair loss with the beginning of therapy. snip... This infiltrate can alter the follicle epithelium and may lead to a granulomatous foreign-body reaction with destruction of the hair follicle. After topical antipsoriatic treatment, most of the reexamined patients showed complete hair regrowth, while 5 developed a residual scarring. Therefore, in the patient with circumscribed or diffuse symptomatic alopecia, with or without scarring, psoriatic alopecia should be considered.